M. Auer

Estradiol propionate reduction of nuclear size in prostate cancer lines lacking DHRS7suggests DHRS7 absence as a biomarker for the effectiveness of estrogen therapy

The paper shows that DHRS7 loss increases nuclear size in prostate cancer cells and that estradiol propionate reduces nuclear size in DHRS7-lacking cells, suggesting DHRS7 as a biomarker for estrogen therapy effectiveness.

Origin of biogeographically distinct ecotypes during laboratory evolution

This study shows how mutations in microbial species lead to resource partitioning and improved community productivity in a simulated subsurface environment.

Nanoscaled discovery of a shunt rifamycin from Salinispora arenicola using a three-colour GFP-tagged Staphylococcus aureus macrophage infection assay.

The paper uses a GFP-tagged S. aureus macrophage infection assay to discover a novel rifamycin analogue with macrophage intracellular activity.

Biofilm Interaction Mapping and Analysis (BIMA): A tool for deconstructing interspecific interactions in co-culture biofilms

The paper introduces BIMA, a method to analyze interspecific interactions in biofilm co-cultures by examining colony morphology, inhibition, invasion, and associated genes/metabolites.

Fasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism

This study shows that fasting enhances the effectiveness of sorafenib in hepatocellular carcinoma by reversing drug resistance through p53-dependent metabolic changes.

PyBindingCurve, simulation and curve fitting to complex binding systems at equilibrium.

PyBindingCurve simulates and fits equilibrium binding systems, revealing that homodimers are more easily inhibited and depleted than heterodimers under specific conditions.

Chemical-Genetic Interrogation of Nuclear Size Control Reveals Cancer-Specific Effects on Cell Migration and Invasion

The paper identifies compounds that reverse nuclear size changes in cancer cell lines and finds they inhibit cell migration and invasion.

Correction of missing-wedge artifacts in filamentous tomograms by template-based constrained deconvolution

This paper introduces a method to correct missing-wedge artifacts in filamentous tomograms using template-based constrained deconvolution, improving automated segmentation of structures like actin-filament bundles.

Asparagine deprivation causes a reversible inhibition of Human Cytomegalovirus acute virus replication

This study identifies asparagine as a critical factor for HCMV replication through a large-scale siRNA screen, showing that its depletion inhibits virus replication but allows recovery with exogenous asparagine.

3D Ultrastructure of the Cochlear Outer Hair Cell Lateral Wall Revealed By Electron Tomography

This study uses electron tomography to reveal the 3D ultrastructure of the cochlear outer hair cell lateral wall, showing anisotropic structural rigidity and complex membrane-cytoskeletal connections.

Cryo-Electron tomography 3D structure and nanoscale model of Arabidopsis thaliana cell wall

Cryo-electron tomography and mechanical simulations revealed cell wall 3D architecture, optimized for flexibility/ductility.

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

This paper introduces a fluorescent confocal on-bead assay to real-time track ubiquitination cascades and identifies new inhibitor activities against Ube1.

Detecting Drug-Target Binding In Cells Using Fluorescence Activated Cell Sorting Coupled With Mass Spectrometry Analysis

This paper introduces a new method called TAPS to assess drug-target binding in cells, demonstrating its effectiveness with the challenging KMO target.