R. Nagar

The major surface protein of malaria sporozoites is GPI-anchored to the plasma membrane

This study confirms that the circumsporozoite protein (CSP) of Plasmodium sporozoites is GPI-anchored using metabolic labeling and mass spectrometry.

A platform for the recombinant production of Group A Streptococcus glycoconjugate vaccines

This study develops a platform for recombinant production of Group A Streptococcus glycoconjugate vaccines using E. coli, confirming their structural integrity and immunogenicity in animal models.

Identification of the glycosylphosphatidylinositol-specific phospholipase A2 (GPI-PLA2) of GPI fatty acid remodelling in Trypanosoma brucei

This paper identifies a gene encoding GPI-PLA2 in Trypanosoma brucei, showing its role in GPI fatty acid remodelling and anchor sidechain size regulation.

Defining Early Steps in B. subtilis Biofilm Biosynthesis

This paper identifies the first two steps in the exopolysaccharide biosynthesis pathway of B. subtilis, determining the substrates for the key enzymes involved.

A UDP-GlcNAc : βGal β1-6 GlcNAc transferase involved in bloodstream form N-glycan and procyclic form GPI anchor elaboration in Trypanosoma brucei.

This paper identifies TbGT10 as a UDP-GlcNAc:βGal β1-6 GlcNAc-transferase essential for N-glycan and GPI anchor modifications in Trypanosoma brucei.

Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in Trypanosoma brucei

This study shows that eliminating GPI2 in Trypanosoma brucei reduces GPI GlcNAc transferase activity, alters GPI glycan modification, and affects social motility.

Mutant p53 suppresses innate immune signaling to promote tumorigenesis

This study identifies mtp53's role in suppressing innate immune signaling by inhibiting TBK1, promoting tumorigenesis through immune evasion.

Distinct life histories impact dikaryotic genome evolution in the rust fungus Puccinia striiformis causing stripe rust in wheat

This study compares two isolates of the wheat rust fungus Puccinia striiformis with different life histories, finding that long-term asexual evolution leads to genome expansion, transposable element accumulation, and increased heterozygosity.