R. Ortiz

VLP-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice

This study develops a neoantigen selection pipeline and a VLP-based vaccine platform to enhance immunogenicity and antitumor activity in mice.

Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant.

This paper identifies mutations that improve the production and efficacy of SARS-CoV-2 Spike proteins, protecting animal models from the Beta variant.

Comparative Transcriptome Profiling Provides Insights into the Growth Promotion Activity of Pseudomonas fluorescens strain SLU99 in Tomato and Potato Plants

This study compares the growth-promoting activity of four rhizobacteria in tomato and potato plants, identifying Pseudomonas fluorescens SLU99 as effective in promoting growth and inducing hormone-related gene expression.

Trans-cellular control of synapse properties by a cell type-specific splicing regulator

This study identifies SLM2 as a cell type-specific splicing regulator that influences synaptic properties through trans-cellular control, leading to synaptic and memory defects when lost in specific neuronal populations.

Modeling genotype environment interaction for single- and multi-trait genomic prediction in potato (Solanum tuberosum L.)

This paper compares genomic prediction models for potato traits across multiple environments, finding that multi-trait models with genotype-environment interactions provide the best accuracy for predicting tuber weight and starch content.

Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2

This paper evaluates a recombinant RBD fusion heterodimer vaccine in mice, showing 100% efficacy against SARS-CoV-2 variants and neutralizing antibodies.

The characteristics of the HIV-1 Env glycoprotein contribute to viral pathogenesis

This study examines how HIV-1 Env glycoprotein characteristics correlate with viral pathogenesis by comparing functional and sequence features across different clinical progression groups.

A close-to-native structure of the synaptonemal complex

This study presents a close-to-native structure of the synaptonemal complex using improved cryo-fixation methods, revealing new structural features.

Multiscale light-sheet organoid imaging framework

This paper introduces a framework for long-term live-imaging of intestinal organoids using light-sheet microscopy and deep learning, enabling 3D segmentation and visualization of cellular dynamics.

Previous SARS-CoV-2 infection increases B.1.1.7 cross-neutralization by vaccinated individuals.

The paper assesses how prior SARS-CoV-2 infection affects B.1.1.7 cross-neutralization in vaccinated individuals, finding that previously infected individuals show equivalent neutralization against B.1.1.7 compared to the Wuhan strain.