M. Vazquez

VLP-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice

This study develops a neoantigen selection pipeline and a VLP-based vaccine platform to enhance immunogenicity and antitumor activity in mice.

Generation of a robust reference gut microbiome dataset for an urban population in Argentina optimized by a machine learning approach

The paper constructs a reference gut microbiome dataset for an urban Argentine population and develops a machine learning model to classify new samples into enterotypes.

Using machine learning to detect coronaviruses potentially infectious to humans

This paper uses machine learning to predict coronaviruses that may infect humans by analyzing spike protein receptor binding, identifying two previously unknown human-binding coronaviruses.

Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

This paper uses human ventricular electromechanical modelling to explain clinical phenotypes in acute and chronic myocardial infarction, showing that ionic remodelling impacts ECG changes and ejection fraction.

Fluid-structure interaction analysis of eccentricity and leaflet rigidity on thrombosis biomarkers in bioprosthetic aortic valve replacements

This paper develops a computational FSI model to study how eccentricity and leaflet rigidity in bioprosthetic aortic valves affect thrombosis biomarkers and valve performance.

Computational study of the furin cleavage domain of SARS-CoV-2: delta binds strongest of extant variants

The paper uses AlphaFold to predict furin cleavage domain structures and finds delta variant has strong binding, with some rare sequences matching it statistically.

Design and execution of a Verification, Validation, and Uncertainty Quantification plan for a numerical model of left ventricular flow after LVAD implantation

This paper presents a numerical model of the LV-LVAD system and executes a verification, validation, and uncertainty quantification plan to ensure credible predictions of left ventricular flow.

Design, immunogenicity and efficacy of a Pan-SARS-CoV-2 synthetic DNA vaccine

This study designs and tests a DNA vaccine, INO-4802, which induces broad immunity against multiple SARS-CoV-2 variants in animal models.

Longitudinal whole-exome sequencing of cell-free DNA unravels the metastatic evolutionary dynamics of BRCA2 mutated breast cancer

This study uses longitudinal whole-exome sequencing of cell-free DNA to track the evolutionary dynamics of BRCA2-mutated breast cancer over 12 years, identifying key mutations and immune escape mechanisms.