Hemozoin produced by mammals confers heme tolerance
R. Pek, X. Yuan, N. Rietzschel, J. Zhang, L. Jackson, E. Nishibori, A. Ribeiro, W. Simmons, J. Jagadeesh, H. Sugimoto, M. Z. Alam, L. Garrett, M. Haldar, M. Ralle, J. Phillips, , I. Hamza
The paper shows that mice lacking HRG1 accumulate excess heme in macrophages, which they tolerate by forming hemozoin, a process previously only observed in blood-feeding parasites.
bioRxiv · May 16, 2019Pathology