H. Sugimoto

Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity

This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.

Single extracellular vesicle imaging and computational analysis identifiesinherent architectural heterogeneity

The paper uses cryo-TEM and a segmentation model to analyze EV architecture, finding consistent structural heterogeneity across different sources and purification methods.

Engineered immunomodulatory extracellular vesicles derived from epithelial cells acquire capacity for positive and negative T cell co-stimulation in cancer and autoimmunity

This study engineers extracellular vesicles from epithelial cells to express immunomodulatory proteins, showing they can induce both positive and negative T cell co-stimulation in cancer and autoimmunity.

A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron binding protein FutA from Prochlorococcus

This paper reveals a redox switch in the cyanobacterial iron binding protein FutA that allows it to bind both Fe(II) and Fe(III) ions through structural analysis.

Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer

The paper shows that type-I conventional dendritic cells enhance checkpoint blockade immunotherapy effectiveness in pancreatic cancer when combined with pancreatitis.

Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner

This study shows that MRTX1133, a KrasG12D inhibitor, reduces early pancreatic lesions and, when combined with immunotherapy, regresses advanced PDAC by enhancing CD8+ T cell activity.

Hemozoin produced by mammals confers heme tolerance

The paper shows that mice lacking HRG1 accumulate excess heme in macrophages, which they tolerate by forming hemozoin, a process previously only observed in blood-feeding parasites.

Chemo-mechanical Coupling in the Transport Cycle of a Type II ABC Transporter

This study uses molecular dynamics simulations to uncover new conformations and the role of LSGG[Q/E] motifs in ATPase activity regulation in an ABC transporter.