Author

L. Garrett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:benchmark study· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. Rathkolb· 2 shared H. Fuchs· 2 shared I. Treise· 2 shared J. Rozman· 2 shared L. Becker· 2 shared N. Spielmann· 2 shared O. V. Amarie· 2 shared A. Aziz· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersPhysiology

B. Rathkolb

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Author profile →

4 papers

Recent·Most cited

Comparative phenotyping of mice reveals canonical and noncanonical physiological functions of TRα and TRβ

G. S. Hönes, D. Geist, C. Wenzek, P. T. Pfluger, T. D. Müller, O. V. Amarie, L. Becker, N. Dragano, L. Garrett, S. M. Hölter, B. Rathkolb, J. Rozman, N. Spielmann, I. Treise, E. Wolf, , L. C. Moeller

This study compares TRα and TRβ knockout mice with DNA-binding-deficient mutants to show noncanonical TR signaling contributes to physiological functions beyond canonical genomic pathways.

bioRxiv · Nov 26, 2023Physiology

Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J Mice

K. Xie, H. Fuchs, E. Scifo, D. Liu, A. Aziz, J. A. Aguilar- Pimentel, O. V. Amarie, L. Becker, P. da Silva-Buttkus, J. Calzada-Wack, Y.-L. Cho, Y. Deng, A. C. Edwards, L. Garrett, C. Georgopoulou, , Schmidt-Weber

This study uses large-scale phenotyping in mice to show that longevity regulators affect age-sensitive phenotypes before detectable aging begins, rather than slowing aging rates.

bioRxiv · Mar 25, 2022Physiology

Hemozoin produced by mammals confers heme tolerance

R. Pek, X. Yuan, N. Rietzschel, J. Zhang, L. Jackson, E. Nishibori, A. Ribeiro, W. Simmons, J. Jagadeesh, H. Sugimoto, M. Z. Alam, L. Garrett, M. Haldar, M. Ralle, J. Phillips, , I. Hamza

The paper shows that mice lacking HRG1 accumulate excess heme in macrophages, which they tolerate by forming hemozoin, a process previously only observed in blood-feeding parasites.

bioRxiv · May 16, 2019Pathology

Impaired hematopoiesis and leukemia development in mice with a conditional \"knock-in\" allele of a mutant splicing factor gene U2af1

D. L. Fei, T. Zhen, B. Durham, J. Ferrarone, T. Zhang, L. Garrett, A. Yoshimi, O. Abdel-Wahab, R. Bradley, P. Liu, H. Varmus

This paper generates a mouse model with a conditional knock-in of the U2af1(S34F) mutation to study its role in hematopoiesis and leukemia, finding that it requires additional mutations for leukemogenesis.

bioRxiv · Jul 26, 2018Cancer Biology