Author

R. Perrone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

E. Verdin· 3 shared M. Ott· 2 shared M. Walter· 2 shared A. Cruz· 1 shared A. J. Covarrubias· 1 shared A. Kale· 1 shared A. Oliveira Pisco· 1 shared A. Vallejo-Gracia· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

E. Verdin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting conserved sequences circumvents the evolution of resistance in a viral gene drive against human cytomegalovirus

M. Walter, R. Perrone, E. Verdin

This study shows that targeting conserved sequences in a viral gene drive prevents resistance evolution in human cytomegalovirus, leading to durable attenuation of viruses.

bioRxiv · Jan 8, 2021Microbiology

FOXO1 promotes HIV Latency by suppressing ER stress in T cells

A. Vallejo-Gracia, I. P. Chen, R. Perrone, E. Besnard, D. Boehm, E. Battivelli, T. Tezil, K. Krey, K. A. Raymond, P. A. Hull, M. Walter, I. Habrylo, A. Cruz, S. Deeks, S. K. Pillai, , M. Ott

This study shows FOXO1 promotes HIV latency by suppressing ER stress in T cells and identifies pathways to selectively reverse quiescence and reduce viral reservoirs.

bioRxiv · Apr 23, 2020Immunology

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

A. J. Covarrubias, A. Kale, R. Perrone, J. A. Lopez-Dominguez, A. Oliveira Pisco, H. G. Kasler, M. S. Schmidt, C. D. Wiley, S. S. Iyer, N. Basisty, Q. Wu, R. Kwok, I. Heckenbach, K.-O. Shin, Y.-M. Lee, , E. Verdin

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

bioRxiv · Jul 31, 2019Immunology