M. Walter

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal

This paper shows that inhibiting the Super Elongation Complex (SEC) with KL-2 increases HIV-1 transcription and reactivates latent virus, especially when combined with other latency reversing agents.

Viral gene drive spread during herpes simplex virus 1 infection in mice

This study demonstrates that a viral gene drive can spread in vivo during HSV-1 infection in mice by promoting co-infection and recombination.

Gene Therapy for Cardiomyopathy associated with Duchenne Muscular Dystrophy in a Pig Model

This study shows that AAV1.SERCA2a gene therapy improves heart function and reduces arrhythmia in a pig model of Duchenne muscular dystrophy.

A condensate forming tether for lariat debranching enzyme is defective in non-photosensitive trichiothiodystrophy

This study identifies TTDN1's role in linking intron lariat processing to the spliceosome, showing its defect causes splicing and gene expression issues in NP-TTD.

Cyclin B3 implements timely vertebrate oocyte arrest for fertilization

This study identifies cyclin B3 as essential for maintaining meiosis I arrest in oocytes by regulating Emi2 degradation, ensuring timely meiosis II arrest for fertilization.

Coenzyme A binding sites induce proximal acylation across protein families

The paper identifies that CoA-binding sites promote proximal lysine acylation in mitochondria through computational analysis and experimental validation.

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

This study identifies SIRT5 as a proviral factor that interacts with SARS-CoV-2 Nsp14, enhancing viral replication and suggesting it as a therapeutic target.

Genome-wide analysis of focal DNA hypermethylation in IDH-mutant AML samples

This study identifies focal DNA hypermethylation in IDH-mutant AML samples and links it to TET2 and DNMT3A activity, with implications for AML pathogenesis.

Targeting conserved sequences circumvents the evolution of resistance in a viral gene drive against human cytomegalovirus

This study shows that targeting conserved sequences in a viral gene drive prevents resistance evolution in human cytomegalovirus, leading to durable attenuation of viruses.

Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential

This study identifies novel SARS-CoV-2 protease cleavage sites and cellular targets using mass spectrometry, showing that targeting these proteins can inhibit viral replication.

Rapid in vitro assays for screening neutralizing antibodies and antivirals against SARS-CoV-2

This paper describes a rapid and reproducible plaque reduction microneutralization assay for identifying neutralizing antibodies and antivirals against SARS-CoV-2, suitable for high-throughput screening.

FOXO1 promotes HIV Latency by suppressing ER stress in T cells

This study shows FOXO1 promotes HIV latency by suppressing ER stress in T cells and identifies pathways to selectively reverse quiescence and reduce viral reservoirs.

Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand doses

This study engineered IL-10 variants with enhanced receptor affinity, showing improved bioactivity and gene expression at lower doses in human monocytes and CD8 T cells.

Viral gene drive in herpesviruses

This study designs a viral gene drive system for herpesviruses, demonstrating its ability to spread engineered traits and replace wildtype populations in cell culture.

Nijmegen Breakage Syndrome (NBS) is a telomeropathy: analysis of telomere length in NBS homo- and heterozygotes and humanized Nbs ice

This study shows that Nijmegen Breakage Syndrome (NBS) is a telomeropathy, with reduced telomere length in patients, and explores its dual role in cancer susceptibility and survival.

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys

This study shows that preexisting antibodies can prevent congenital cytomegalovirus infection in monkeys by blocking placental transmission.