Author

R. Pomes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

J.-P. Julien· 2 shared A. Srivastava· 1 shared C. Bear· 1 shared C. E. Ing· 1 shared D. Jiang· 1 shared E. Thai· 1 shared H. Cui· 1 shared I. Kucharska· 1 shared

Activity by Year

2016-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

J.-P. Julien

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpon toxin

D. Jiang, L. Tonggu, T. Gamal El-Din, R. Banh, R. Pomes, N. Zheng, W. A. Catterall

This study reveals the structure of a scorpion toxin bound to a cardiac sodium channel, showing how it traps the voltage sensor and alters channel gating without opening the channel.

bioRxiv · Dec 28, 2020Pharmacology & Toxicology

Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11

I. Kucharska, E. Thai, A. Srivastava, J. L. Rubinstein, R. Pomes, J.-P. Julien

This study investigates how antibody 3D11 binds to Plasmodium berghei CSP repeats, inducing structural ordering and revealing common mechanisms of antibody evolution against Plasmodium CSP.

bioRxiv · Jun 2, 2020Microbiology

Lipid interactions enhance activation and potentiation of cystic fibrosis transmembrane conductance regulator (CFTR)

S. Chin, M. Ramjeesingh, M. Hung, J. Ereno-Oreba, C. E. Ing, Z. W. Zeng, H. Cui, J.-P. Julien, R. Pomes, C. Bear

This study shows that lipid interactions are crucial for CFTR channel activation and potentiation, as demonstrated by higher catalytic activity and response to ivacaftor when CFTR is purified with associated lipids.

bioRxiv · Dec 16, 2018 · PreprintBiophysics

The Liquid Structure of Elastin

S. Rauscher, R. Pomes

This study uses molecular dynamics simulations to reveal the structural ensemble of aggregated elastin-like peptides, showing a maximally-disordered, melt-like state stabilized by hydrophobic effects and conformational entropy.

bioRxiv · Dec 21, 2016Biophysics