C. Bear

Benchmarking organ-specific responses to therapies in tissues differentiated from Cystic Fibrosis patient derived iPSCs

This study benchmarks Trikafta's efficacy in CF patient-derived iPSC-derived colonic and airway tissues compared to isogenic controls, showing differential therapeutic responses.

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells

This study compares a novel CFTR potentiator, SK-POT1, to ivacaftor in improving mucociliary clearance in airway epithelial cells exposed to cigarette smoke.

Generation of functional ciliates cholangiocytes from human pluripotent stem cells

This study generates functional cholangiocytes from human pluripotent stem cells that exhibit mature characteristics and can be used for drug testing and disease modeling.

Lipid interactions enhance activation and potentiation of cystic fibrosis transmembrane conductance regulator (CFTR)

This study shows that lipid interactions are crucial for CFTR channel activation and potentiation, as demonstrated by higher catalytic activity and response to ivacaftor when CFTR is purified with associated lipids.