Author

R. Rayner

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Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. Amer· 1 shared A. Badr· 1 shared A. Eddy· 1 shared A. Forero· 1 shared A. Kenney· 1 shared A. Tedeschi· 1 shared A. Webb· 1 shared A. Zani· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

A. Amer

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1 paper

Recent·Most cited

ImmunologyProceedings of the National Academy of SciencesPeer-reviewedMay 19, 2022

Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis

M. Eltobgy, A. Zani, A. Kenney…·A. Amer

This study shows that caspase-4/11 worsens SARS-CoV-2 infection by increasing inflammation and thrombosis, independent of GSDMD, suggesting it as a potential drug target for severe COVID-19.

DOI 10.1073/pnas.2202012119

mouseexperimental assay

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