BiochemistrybioRxiv
The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes
F. Raguseo, A. Huyghebaert, J. Li…·M. Di Antonio
This study shows that C9orf72 hexanucleotide repeat expansions form RNA condensates via multimolecular G-quadruplexes, suggesting a therapeutic target for ALS/FTD.
DOI 10.1038/s41467-023-43872-1