Raju S Rajmani

This paper shows that SARS-CoV-2's Nsp5 protease cleaves La protein to switch viral RNA from translation to replication.

The paper develops a neutral pH plasma-activated water hydrogel that effectively reduces microbial infections and promotes wound healing in mouse models.

This study shows LSD1 regulates host alpha-ketoglutarate levels, modulating lipid peroxidation and mycobacterial survival during tuberculosis infection.

This study identifies PRMT5-dependent methylation of NCOA4 as a mechanism by which Mtb induces ferroptosis in host macrophages to enhance its survival and dissemination.

This study shows that YqhD in Salmonella reduces reactive oxygen species and efflux pump activity, impairing bile resistance, and that its mutation increases survival in bile stress conditions.

This study shows AI-2 signaling in Salmonella coordinates gene expression for colonization and virulence in mice, with potential for therapeutic targeting.

The paper shows that the host AAA-ATPase VCP/p97 has bacteriolytic activity by mechanically extracting ubiquitinated proteins from bacterial membranes, leading to microbial clearance in a mouse sepsis model.

This study shows SIRT2 reduces JEV infection in mice by inhibiting NF-κB and enhancing autophagy, improving survival and reducing viral load.

This study identifies Salmonella effector SseL as a key mediator of PD-L1 upregulation via beta-catenin signaling, leading to T cell inactivation and immune evasion.

The paper identifies Activin A's role in regulating KAT8 and NRF2 to induce ferroptosis during Mycobacterium tuberculosis infection, showing inhibition reduces TB burden.

This study shows that altering macrophage metabolism can reduce drug tolerance in Mycobacterium tuberculosis by affecting bacterial redox states.

This study identifies Odoribacter splanchnicus as a broad-spectrum protective agent against Salmonella and Listeria infections by enhancing colonization resistance, preserving gut barrier integrity, and limiting pathogen proliferation and virulence.

This study shows Salmonella Typhimurium uses spermidine to resist ROS stress and rewires host polyamine metabolism, enhancing survival in macrophages, and suggests DFMO as a therapeutic option.

This study shows miR-22 binds to CVB3 5'UTR, displaces ITAFs, inhibits translation, and reduces viral infection.