Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity
Rebecca L. McIntyre, Simone W. Denis, Rashmi Kamble…·Georges E. Janssens
The paper identifies atracurium as an FDA-approved compound that extends lifespan and healthspan in C. elegans by activating the FOXO/DAF-16 longevity pathway through neuromuscular acetylcholine receptor inhibition.