Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction and leads to increased glucose uptake in tafazzin-deficient cells
Zhuqing Liang, Tyler Ralph-Epps, Michael W. Schmidtke…·Miriam L. Greenberg
This study identifies the upregulation of the AMPK-FOXO1-PDK4 pathway as the mechanism causing reduced PDH activity and increased glucose uptake in tafazzin-deficient cells.