Dual kinase inhibition provides early clues to restoration of neuroimmune homeostasis in an AAV-haSyn model of Parkinsons disease
Wesley Chiang, Ivette M. Sandoval, Herman Li, Luis Daniel Bernal-Conde, Rene Squire, Madeline K. Washburn, Jack L. Schwartz, Erica Squire, Eric J. Wagner, Fredric P. Manfredsson, Harris A. Gelbard
This study shows that dual inhibition of MLK3 and LRRK2 with URMC-099 reduces PD pathology and motor deficits in an AAV-haSyn rat model.
bioRxiv · Nov 7, 2026 · PreprintNeuroscience