Author

Wesley Chiang

University of Rochester MedicineORCID 0000-0003-0847-2056Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:imaging· 1 Organism:rat· 1

Frequent Co-Authors

Harris A. GelbardiD· 5 shared Herman LiiD· 4 shared Angela StoutiD· 2 shared Bradley L. NilssoniD· 2 shared Erica SquireiD· 2 shared Francine Yanchik-SladeiD· 2 shared Niccolò TerrandoiD· 2 shared Rene Squire· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersNeuroscience

Harris A. GelbardORCID

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5 papers

Recent·Most cited

Dual kinase inhibition provides early clues to restoration of neuroimmune homeostasis in an AAV-haSyn model of Parkinsons disease

Wesley Chiang, Ivette M. Sandoval, Herman Li, Luis Daniel Bernal-Conde, Rene Squire, Madeline K. Washburn, Jack L. Schwartz, Erica Squire, Eric J. Wagner, Fredric P. Manfredsson, Harris A. Gelbard

This study shows that dual inhibition of MLK3 and LRRK2 with URMC-099 reduces PD pathology and motor deficits in an AAV-haSyn rat model.

bioRxiv · Nov 7, 2026 · PreprintNeuroscience

Dynamics of Neutrophilia at the Neurovascular Unit Arising from Repeated Pulmonary Inflammation

Wesley Chiang, Herman Li, Linh Le, Jennifer David‐Bercholz, Ana Isabel Caceres, Danial Ahmad, Erica Squire, Kamryn S. Stecyk, Mariah Marrero, Amanda Pereira, Rene Squire, Claire Lim, James L. McGrath, Ania Katarzyna Majewska, Niccolò Terrando, Harris A. Gelbard

This study investigates how repeated pulmonary inflammation leads to neutrophil dynamics at the neurovascular unit, showing increased neutrophilia and microglial activation in the brain.

Journal of Neuroinflammation · Mar 25, 2026Peer-reviewedNeuroscience

Hybrid Amyloid Quantum Dot Nanoassemblies to Probe Neuroinflammatory Damage

Wesley Chiang, Jennifer M. Urban, Francine Yanchik-Slade, Angela Stout, Bradley L. Nilsson, Harris A. Gelbard, Todd D. Krauss

The paper develops a quantum dot mimetic to study the role of amyloid-beta oligomers in neuroinflammatory responses in neuronal and glial cells.

bioRxiv · Aug 30, 2023 · PreprintNeuroscience

URMC-099 Prophylaxis Prevents Hippocampal Vascular Vulnerability and Synaptic Damage in an Orthopedic Model of Delirium Superimposed on Dementia

Patrick Miller‐Rhodes, Herman Li, Ravikanth Velagapudi, Wesley Chiang, Niccolò Terrando, Harris A. Gelbard

The paper investigates the effects of URMC-099 in preventing vascular and synaptic damage in a mouse model of delirium superimposed on dementia.

The FASEB Journal · May 10, 2022Peer-reviewedNeuroscience

A Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Dysregulation of the Neurovascular Unit Relevant to Brain Inflammation

Wesley Chiang, Angela Stout, Francine Yanchik-Slade, Herman Li, Bradley L. Nilsson, Harris A. Gelbard, Todd D. Krauss

This study uses a SARS-CoV-2 biomimetic to investigate how BBB dysregulation may lead to neuroinflammation without direct viral infection.

bioRxiv · Apr 20, 2022 · PreprintNeuroscience