BiophysicsbioRxiv
Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite
J. M. Bruning, Y. Wang, F. Oltrabella…·P. M. England
The paper identifies 5,6-dihydroxyindole (DHI) as a dopamine metabolite that covalently modifies and activates Nurr1, a nuclear receptor critical for dopaminergic neuron function, offering potential therapeutic strategies for Parkinson's disease.
DOI 10.1016/j.chembiol.2019.02.002