S. E. Lee

Beclin1-Deficient Adipocytes Promote Tumor Progression by YAP/TAZ-dependent Adipocyte Transformation

This study shows that Beclin1-deficient adipocytes promote tumor progression via YAP/TAZ signaling, and inhibiting this pathway reduces tumor growth in mice.

Spinal cord injury in mice amplifies anxiety: a novel light-heat conflict test exposes increased salience of anxiety over heat

This study introduces a novel TIDAL test to assess anxiety and pain-like behaviors in mice with spinal cord injury, finding that SCI increases anxiety salience over heat sensitivity in both sexes.

Amplification of Olfactory Signals by Anoctamin 9 is Essential for Mammalian Olfaction: a Risk Factor for the Covid-19-associated Anosmia

This study identifies Anoctamin 9 as essential for mammalian olfaction, showing its role in amplifying olfactory signals and linking its downregulation to Covid-19-associated anosmia.

Low diversity and instability of the sinus microbiota over time in adults with cystic fibrosis

This study examines the microbiota of adults with cystic fibrosis (CF) and finds low diversity and instability in sinus microbial communities, linked to inflammation and worse sinus disease.

Therapeutic base and prime editing of COL7A1 mutations in recessive dystrophic epidermolysis bullosa

This study corrects COL7A1 mutations in RDEB patient fibroblasts using base and prime editing, restoring C7 expression and function in vitro and in vivo.

Evolution and adaptation of Pseudomonas aeruginosa in the paranasal sinuses of people with cystic fibrosis

This study identifies three evolutionary genetic routes of Pseudomonas aeruginosa adaptation in the sinuses of people with cystic fibrosis, suggesting sinuses may be an early site of pathoadaptation before lung infections.

A three-dimensional Air-Liquid Interface Culture Model for the Study of Epstein-Barr virus Infection in the Nasopharynx

This study uses a 3D air-liquid interface culture model to show that nasopharyngeal epithelial cells can be infected by EBV, with single-cell RNA-sequencing identifying distinct EBV transcription profiles.

Plant NLR targets P-type ATPase for executing plasma membrane depolarization leading to calcium influx and cell death

The paper shows that the plant NLR CCA309 targets P-type ATPase to cause membrane depolarization, calcium influx, and cell death during hypersensitive response.

A stealth adhesion factor contributes to Vibrio vulnificus pathogenicity: Flp pili play roles in host invasion, survival in the blood stream and resistance to complement activation

This study shows that all three Tad operons in Vibrio vulnificus are required for pathogenicity, as they enable host invasion, survival in blood, and resistance to complement activation through Flp pili.

Multiple reference genome sequences of hot pepper reveal the massive evolution of plant disease resistance genes by retroduplication

The paper reports multiple pepper genomes and finds that retroduplication via LTR-retrotransposons drives expansion of disease resistance genes in plants.