Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25
K. Haubrich, S. Augsten, L. Alvarez, I. Huppertz, B. Simon, K. Perez, P. Masiewicz, M. Lethier, K. Rittinger, F. Gabel, M. W. Hentze, S. Cusack, J. Hennig
This study identifies RNA binding sites on TRIM25 and shows that RNA binding enhances its E3 ligase activity and affects RIG-I ubiquitination.
bioRxiv · May 4, 2020 · PreprintMolecular Biology