K. Perez

Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan

This study shows that chemical reprogramming can improve aging-related cellular features and extend lifespan in C. elegans.

Immunodominant surface epitopes power immune evasion in the African trypanosome

The paper shows that immune responses to African trypanosome VSGs are focused on immunodominant epitopes, enabling immune evasion through epitope variation.

Message in a Bottle, Metabarcoding Enables Biodiversity Comparisons Across Ecoregions

This study uses DNA metabarcoding to compare arthropod biodiversity across three Canadian ecoregions, finding greater similarity within ecoregions and a decline in diversity from east to west.

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

This study identifies a transitional cancer cell state in metastatic pancreatic cancer and shows that tumor microenvironment signals drive transcriptional plasticity and subtype transitions.

A Parasite Coat Protein Binds Suramin to Confer Drug Resistance

This study identifies that the trypanosome VSGsur protein binds suramin, conferring drug resistance, and shows this interaction is critical for resistance.

Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25

This study identifies RNA binding sites on TRIM25 and shows that RNA binding enhances its E3 ligase activity and affects RIG-I ubiquitination.

Structure-based screening of binding affinities via small-angle X-ray scattering

This paper demonstrates a method using SAXS to quantify ligand binding affinities without prior structural knowledge, showing its potential for drug discovery.

Expedited Assessment of Terrestrial Arthropod Diversity by Coupling Malaise Traps with DNA Barcoding

This paper describes protocols combining Malaise traps and DNA barcoding to rapidly assess arthropod diversity, demonstrating their use in a national park survey of 20,000 specimens representing 2200 species.