Author

P. Masiewicz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

J. Hennig· 3 shared B. Simon· 2 shared K. Perez· 2 shared A. W. Thomae· 1 shared F. Gabel· 1 shared I. Huppertz· 1 shared K. Haubrich· 1 shared K. Rittinger· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersMolecular Biology

J. Hennig

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3 papers

Recent·Most cited

Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25

K. Haubrich, S. Augsten, L. Alvarez, I. Huppertz, B. Simon, K. Perez, P. Masiewicz, M. Lethier, K. Rittinger, F. Gabel, M. W. Hentze, S. Cusack, J. Hennig

This study identifies RNA binding sites on TRIM25 and shows that RNA binding enhances its E3 ligase activity and affects RIG-I ubiquitination.

bioRxiv · May 4, 2020 · PreprintMolecular Biology

Structure-based screening of binding affinities via small-angle X-ray scattering

P.-c. Chen, P. Masiewicz, K. Perez, J. Hennig

This paper demonstrates a method using SAXS to quantify ligand binding affinities without prior structural knowledge, showing its potential for drug discovery.

bioRxiv · Jul 31, 2019Biophysics

Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless

P. K. A. Jagtap, M. Mueller, P. Masiewicz, S. von Buelow, N. M. Hollmann, B. Simon, A. W. Thomae, P. B. Becker, J. Hennig

This study determines the NMR structure of MLE's dsRBD1 and dsRBD2 and shows they bind dsRNA independently, but dsRBD1 mutants do not affect roX2 binding or MLE localization.

bioRxiv · Nov 9, 2018Biochemistry