Author

S. Brouwer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

L. McIntyre· 2 shared M. J. Walker· 2 shared M. R. Davies· 2 shared A. Cvejic· 1 shared A. G. McEwan· 1 shared A. J. Cork· 1 shared A. J. van Oosterhout· 1 shared B. L. Schulz· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

L. McIntyre

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Author profile →

3 papers

Recent·Most cited

A role for glutathione in buffering excess intracellular copper in Streptococcus pyogenes

L. J. Stewart, C.-l. Y. Ong, M. M. Zhang, S. Brouwer, L. McIntyre, M. R. Davies, M. J. Walker, A. G. McEwan, K. J. Waldron, K. Y. Djoko

This study shows that glutathione buffers excess intracellular copper in Streptococcus pyogenes when the Cu export system is overwhelmed, allowing bacterial survival despite copper toxicity.

mBio · Dec 22, 2020Peer-reviewedMicrobiology

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

S. Brouwer, T. C. Barnett, D. Ly, K. J. Kasper, D. M. De Oliveira, T. Rivera-Hernandez, A. J. Cork, L. McIntyre, M. G. Jespersen, J. Richter, B. L. Schulz, G. Dougan, V. Nizet, K.-Y. Yuen, Y. You, , M. J. Walker

This study identifies prophage-encoded exotoxins in Streptococcus pyogenes that enhance colonization fitness and pathogenesis in scarlet fever.

bioRxiv · May 17, 2020Microbiology

A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease

F. A. Vieira Braga, G. Kar, M. Berg, O. A. Carpaij, K. Polanski, L. M. Simon, S. Brouwer, T. Gomes, L. Hesse, J. Jiang, E. S. Fasouli, M. Efremova, R. Vento-Tormo, K. Affleck, S. Palit, , S. A. Teichmann

The paper uses single-cell transcriptomics to identify novel cell states in healthy and asthmatic lung tissues, revealing changes in cell communication and immune responses.

bioRxiv · Jan 23, 2019 · PreprintImmunology