Antigen receptor signaling and cell death resistance controls intestinal humoral response zonation.
F. Raso, S. Liu, M. J. Willett, G. Barton, C. T. Mayer, O. Bannard, M. Acharya, J. Muppidi, A. Marshak-Rothstein, A. Reboldi
This study shows that IgA BCR signaling enhances B cell fitness and promotes diverse IgA responses to gut commensals by rescuing low-affinity B cells and redirecting plasma cell homing.
bioRxiv · Mar 16, 2023Immunology