Reflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors
D. Sicari, R. Pineau, P.-J. Le Reste, L. Negroni, S. Chat, A. Mohtar, D. Thomas, R. Gillet, T. Hupp, E. Chevet, A. Igbaria
The paper identifies a mechanism where ER proteins are refluxed to the cytosol, inactivating tumor suppressors like p53 in glioblastoma cells.
bioRxiv · Apr 13, 2020Cell Biology