Author

R. Pineau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 2 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:cancer & tumor microenvironment· 4 Research Focus:gene regulatory network inference· 4 Organism:mouse· 4 Approach:statistical model· 4

Frequent Co-Authors

e. chevet· 5 shared T. Avril· 4 shared A. Pandit· 3 shared J. Samal· 3 shared K. Voutetakis· 3 shared P.-J. Le Reste· 3 shared A. Chatziioannou· 2 shared A. Obiedat· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

e. chevet

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Experimental evolution of multicellularity via cuboidal cell packing in fission yeast

R. Pineau, P. C. Kahn, D. T. Lac, M. Denning, W. Wong, W. Ratcliff, G. O. Bozdag

This study experimentally evolves cuboidal cell packing in fission yeast, showing it leads to multicellular clusters with heritable group size and responses to group-level selection.

bioRxiv · Nov 3, 2023Evolutionary Biology

Emergence and maintenance of stable coexistence during a long-term multicellular evolution experiment

R. Pineau, D. Demory, E. Libby, D. T. Lac, T. Day, P. Bravo, J. Weitz, P. J. Yunker, G. O. Bozdag, W. C. Ratcliff

This study shows how multicellularity evolves through niche partitioning and adaptive divergence in snowflake yeast, leading to stable coexistence via a trade-off between size and competitiveness for oxygen.

bioRxiv · Jan 19, 2023Evolutionary Biology

TGFβ-induced long non-coding RNA LINC00313 activates Wnt signaling and promotes cholangiocarcinoma

P. Papoutsoglou, C. Louis, R. Pineau, A. L'Haridon, J. M. Banales, D. Gilot, M. Aubry, C. Coulouarn

This study identifies LINC00313 as a TGFβ-induced lncRNA that activates Wnt signaling and promotes cholangiocarcinoma through interactions with SWI/SNF and regulation of TCF7 and SULF2.

bioRxiv · Sep 28, 2022 · PreprintCancer Biology

IRE1 RNase controls CD95-mediated cell death

D. Pelizzari-Raymundo, R. Pineau, A. Papaioannou, X. Zhou, S. Martin, T. Avril, M. Le Gallo, e. chevet, E. Lafont

This study shows that IRE1 RNase activity regulates CD95 expression and cell death in cancer cells, with implications for therapeutic targeting.

bioRxiv · Feb 25, 2022Cell Biology

Reflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors

D. Sicari, R. Pineau, P.-J. Le Reste, L. Negroni, S. Chat, A. Mohtar, D. Thomas, R. Gillet, T. Hupp, E. Chevet, A. Igbaria

The paper identifies a mechanism where ER proteins are refluxed to the cytosol, inactivating tumor suppressors like p53 in glioblastoma cells.

bioRxiv · Apr 13, 2020Cell Biology

Local intracerebral Inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo.

P.-J. Le Reste, R. Pineau, K. Voutetakis, J. Samal, G. Jegou, S. Lhomond, A. M. Gorman, A. Samali, J. B. Patterson, Q. Zeng, A. Pandit, M. AUBRY, N. Soriano, A. Etcheverry, J. Mosser, , e. chevet

The paper develops a novel immunocompetent GBM model to test the effect of IRE1 inhibition on treatment efficacy in vivo.

bioRxiv · Feb 20, 2020Cancer Biology

A multi-layered systems approach for renal cell carcinoma

L. Cooley, J. Rudewicz, W. Souleyreau, K. Clarke, F. Falciani, M. Dufies, S. Verbeke, A. Emanuelli, S. Benzekry, C. Taing, E. J. Ribot, S. Miraux, D. Lambrechts, E. Modave, R. Pineau, , A. Bikfalvi

A multi-layered systems approach identifies prognostic and predictive biomarkers for renal cell carcinoma aggressiveness through in vivo models and integrative analysis.

bioRxiv · Jan 13, 2020 · PreprintCancer Biology

Novel IRE1-dependent proinflammatory signaling controls tumor infiltration by myeloid cells.

J. Obacz, J. Archambeau, P. J. Le Reste, R. Pineau, K. Barroso, E. Vlachavas, K. Voutetakis, T. Fainsod-Levi, A. Obiedat, Z. Granot, B. Tirosh, J. Samal, A. Pandit, J. Patterson, Q. Zheng, , e. chevet

This study identifies an IRE1-dependent proinflammatory signaling pathway in glioblastoma that promotes tumor invasion, angiogenesis, and myeloid cell infiltration.

bioRxiv · Jan 11, 2020Cancer Biology

Constitutive UPRER activation sustains tumor cell differentiation

D. Doultsinos, M. McMahon, K. Voutetakis, J. Obacz, R. Pineau, P.-J. Le Reste, A. Obiedat, J. Samal, J. B. Patterson, Q. Zheng, A. Samali, A. Pandit, B. Tirosh, A. Chatziioannou, E. Chevet, T. Avril

The paper shows that constitutive IRE1 activation maintains differentiation in glioblastoma cells by repressing stemness factors.

bioRxiv · Oct 22, 2019 · PreprintCancer Biology