Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation
S. Nalle, R. Barreira da Silva, H. Zhang, M. Decker, C. Chalouni, M. Xu, G. Posthuma, A. de Maziere, J. Klumperman, A. Baz Morelli, S. Fleire, A. Verkman, S. Trombetta, M. Albert, I. Mellman
This study identifies aquaporin-3 as a regulator of endosome-to-cytosol transfer by facilitating hydrogen peroxide entry, which induces lipid peroxidation and antigen release.
bioRxiv · Aug 19, 2020Immunology