Cell BiologybioRxiv
The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes
S. D. Carter, N.-H. Tran, A. De Maziere…·P. Walter
This study determines the in-situ structure of IRE1 oligomers in ER tubes using cryo-CLEM, revealing helical filaments formed by IRE1 lumenal domain dimers and suggesting positive feedback in IRE1 signaling.
DOI 10.1126/science.abh2474