Author

S. G. Tangye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:clinical cohort / trial· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. C. Goodnow· 2 shared D. Suan· 2 shared E. Masle-Farquhar· 2 shared G. Uzel· 2 shared I. Chua· 2 shared J. H. Reed· 2 shared J. W. Leiding· 2 shared K. Heiskanen· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

C. C. Goodnow

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologybioRxivPreprintMar 19, 2022

Environmental and genetic disease modifiers of haploinsufficiency of A20

N. N. Zammit, P. Gray, O. M. Siggs…·S. T. Grey

The paper identifies genetic and environmental modifiers that exacerbate autoinflammatory disease caused by A20 haploinsufficiency in humans.

DOI 10.1101/2022.03.19.485004

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 11, 2022

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells

E. Masle-Farquhar, K. J. L. Jackson, T. J. Peters…·C. C. Goodnow

This study shows that STAT3 gain-of-function mutations in leukemia drive autoimmune pathology by causing NKG2Dhi CD8 T cell oligoclonal expansion and cytotoxic activity.

DOI 10.1101/2022.02.11.480027

mouseproteomics

𝕏 PostBluesky

ImmunologybioRxivPreprintDec 20, 2021

Overactive STAT3 drives accumulation of disease-associated CD21low B cells

E. Masle-Farquhar, T. J. Peters, K. J. Jackson…·C. C. Goodnow

This study shows that overactive STAT3 leads to the accumulation of disease-associated CD21low B cells in both humans and mice.

DOI 10.1101/2021.12.20.473595

𝕏 PostBluesky