Autologous humanized PDX modeling for immuno-oncology recapitulates the human tumor microenvironment
M. Chiorazzi, J. Martinek, B. Krasnick, Y. Zheng, K. J. Robbins, R. Qu, G. Kaufmann, Z. Skidmore, L. A. Henze, F. Brosecke, A. Adonyi, J. Zhao, L. Shan, E. Sefik, J. Mudd, , R. A. Flavell
This study develops an autologous humanized PDX model to study tumor-immune interactions and demonstrates its utility in preclinical testing by showing VEGF-A inhibition reduces tumor growth.
bioRxiv · Aug 19, 2022 · PreprintCancer Biology