Author

E. Sefik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. Zhao· 3 shared R. A. Flavell· 3 shared R. Qu· 3 shared Y. Kluger· 3 shared H. R. Steach· 2 shared J. R. Brewer· 2 shared L. Shan· 2 shared S. Halene· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

J. Zhao

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

H. R. Steach, A. G. York, J. Mattingly, M. H. Skadow, S. Chen, J. Zhao, K. J. Williams, Q. Zhou, W.-Y. Hsieh, J. R. Brewer, R. Qu, J. A. Shyer, C. Harman, E. Sefik, W. K. Mowell, , R. Flavell

This study shows IL-4 promotes B cell activation by upregulating cholesterol synthesis, which is essential for ER expansion, cell cycle progression, and proliferation during influenza infection.

bioRxiv · May 13, 2024 · PreprintImmunology

Autologous humanized PDX modeling for immuno-oncology recapitulates the human tumor microenvironment

M. Chiorazzi, J. Martinek, B. Krasnick, Y. Zheng, K. J. Robbins, R. Qu, G. Kaufmann, Z. Skidmore, L. A. Henze, F. Brosecke, A. Adonyi, J. Zhao, L. Shan, E. Sefik, J. Mudd, , R. A. Flavell

This study develops an autologous humanized PDX model to study tumor-immune interactions and demonstrates its utility in preclinical testing by showing VEGF-A inhibition reduces tumor growth.

bioRxiv · Aug 19, 2022 · PreprintCancer Biology

Human neutrophil development and functionality are enabled in a humanized mouse model

Y. Zheng, E. Sefik, J. Astle, A. G. Solis, H. H. Oz, R. Jackson, E. M. Bruscia, S. Halene, L. Shan, R. A. Flavell

This study develops a humanized mouse model, MISTRGGR, that supports the generation of functional human neutrophils in circulation and tissues, which respond to inflammatory and infectious challenges.

bioRxiv · Feb 25, 2022Immunology

Inflammasome activation in infected macrophages drives COVID-19 pathology

E. Sefik, R. Qu, C. Junqueira, E. Kaffe, H. Mirza, J. Zhao, J. R. Brewer, A. Han, H. R. Steach, B. Israelow, H. N. Blackburn, S. Velazquez, Y. G. Chen, S. Halene, A. Iwasaki, , R. A. Flavell

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

bioRxiv · Sep 27, 2021Immunology