Author

T. Komori

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Mabuchi· 2 shared D. Kitagawa· 2 shared M. Fukuyama· 2 shared M. Genova· 2 shared S. Hata· 2 shared T. Chinen· 2 shared A. Toyoda· 1 shared C. Tei· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

A. Mabuchi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 1, 2022

ssDNA is not superior to dsDNA as long HDR donors for CRISPR-mediated endogenous gene tagging in human diploid cells

A. Mabuchi, S. Hata, M. Genova…·D. Kitagawa

This study compares ssDNA and dsDNA as HDR donors for CRISPR-mediated gene tagging in human diploid cells, finding dsDNA more efficient for precise insertion.

DOI 10.1101/2022.06.01.494308

humanCRISPR screen

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Cell BiologybioRxivJun 21, 2021

A CRISPR-del-based pipeline for complete gene knockout in human diploid cells

T. Komori, S. Hata, A. Mabuchi…·D. Kitagawa

This study introduces a CRISPR-del pipeline to achieve complete gene knockout in human diploid cells by inducing large chromosomal deletions, showing higher efficiency than conventional methods.

DOI 10.1242/jcs.260000

humanexperimental assay

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Cancer BiologybioRxivPreprintMay 3, 2021

The oncogenic Runx3-Myc axis defines p53-deficient osteosarcomagenesis

S. Otani, Y. Date, T. Ueno…·K. Ito

This study identifies the Runx3-Myc axis as a driver of p53-deficient osteosarcomagenesis in human and mouse models.

DOI 10.1101/2021.05.03.442316

mousehuman

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BiophysicsbioRxivSep 15, 2017

Real-time observation of flexible domain movements in Cas9

S. Osuka, K. Isomura, S. Kajimoto…·S. Uemura

This study uses single-molecule FRET to observe dynamic domain movements in Cas9, showing flexibility enables DNA cleavage and sgRNA assembly.

DOI 10.15252/embj.201796941

microscopy & imaging analysisprotein folding & dynamics

𝕏 PostBluesky