Author

S. K. Chakka

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

C. Ottmann· 1 shared D. Macdonald· 1 shared D. Thomas· 1 shared F. Gielkens· 1 shared G. Carlile· 1 shared H. Thomas· 1 shared L. Brunsveld· 1 shared L. M. Stevers· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

C. Ottmann

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1 paper

Recent·Most cited

BiochemistrybioRxivJan 3, 2022

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

L. M. Stevers, M. Wolter, G. Carlile…·C. Ottmann

This paper identifies a macrocycle that stabilizes the 14-3-3/CFTR complex, enhancing CFTR membrane localization and activity, particularly for the F508del mutation.

DOI 10.1038/s41467-022-31206-6

humanexperimental assay

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