Author

D. Macdonald

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Ecology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:imaging· 2 Assay:clinical cohort / trial· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

A. Alazami· 1 shared C. Bowen· 1 shared C. Ottmann· 1 shared C. P. Mata· 1 shared C. Rooryck· 1 shared D. Thomas· 1 shared F. Gielkens· 1 shared F. Gothe· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperImmunology

A. Alazami

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

miRNA upregulate protein and glycan expression via direct activation in proliferating cells

F. Jame-Chenarboo, H. H. Ng, D. Macdonald, L. K. Mahal

The paper shows miRNA can directly upregulate protein and glycan expression in proliferating cells, challenging the dominant view of miRNA repression.

bioRxiv · Apr 1, 2022 · PreprintBiochemistry

Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

L. M. Stevers, M. Wolter, G. Carlile, D. Macdonald, L. Richard, F. Gielkens, D. Thomas, S. K. Chakka, M. L. Peterson, H. Thomas, L. Brunsveld, C. Ottmann

This paper identifies a macrocycle that stabilizes the 14-3-3/CFTR complex, enhancing CFTR membrane localization and activity, particularly for the F508del mutation.

bioRxiv · Jan 3, 2022Biochemistry

Using very high-resolution satellite imagery and deep learning to detect and count African elephants in heterogeneous landscapes

I. C. Duporge, O. Isupova, S. Reece, D. Macdonald, T. Wang

This study uses deep learning and high-resolution satellite imagery to detect and count African elephants in heterogeneous landscapes, achieving accuracy comparable to human detection.

bioRxiv · Sep 9, 2020Ecology

Estimating the density of small population of leopard Panthera pardus using multi-session photographic-sampling data

M. Farhadinia, P. Behnoud, K. Hobeali, S. J. Mousavi, F. Hosseini-Zavarei, N. Gholikhani, H. Akbari, M. Eslami, P. Moghadas, D. Macdonald

The paper estimates leopard population density in central Iran using multi-session camera trap data and SECR modeling, finding low densities and seasonal/sexual movement patterns.

bioRxiv · Aug 22, 2020 · PreprintEcology

Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance

Z. Zhang, F. Gothe, P. Pennamen, J. James, D. MacDonald, C. P. Mata, Y. Modis, M. Acres, W. Haller, C. Bowen, R. Doffinger, J. Sinclair, S. Brothers, A. Alazami, Y. Zhang, , M. J. Lenardo

This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.

bioRxiv · Nov 26, 2018Immunology