Author

S. Klinge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:cryo-EM· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Vanden Broeck· 3 shared M. Chaker-Margot· 3 shared B. T. Chait· 2 shared J. Barandun· 2 shared K. R. Molloy· 2 shared M. Hunziker· 2 shared B. Wang· 1 shared C. Sawyers· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

A. Vanden Broeck

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Principles of human pre-60S biogenesis

A. Vanden Broeck, S. Klinge

The paper reports cryo-EM structures of human pre-60S particles, revealing mechanisms of ribosome assembly involving protein interaction hubs and RNA processing.

bioRxiv · Mar 14, 2023Biochemistry

A co-transcriptional ribosome assembly checkpoint controls nascent large ribosomal subunit maturation

Z. Sanghai, R. Piwowarczyk, A. Vanden Broeck, S. Klinge

The paper reports the cryo-EM structure of a co-transcriptional large ribosomal subunit assembly intermediate, revealing how quality control is established during ribosome biogenesis.

bioRxiv · Mar 2, 2023Biophysics

Allosteric interactions prime androgen receptor dimerization and activation

E. Wasmuth, A. Vanden Broeck, J. R. LaClair, E. A. Hoover, K. E. Lawrence, N. Paknejad, K. J. Pappas, D. Matthies, B. Wang, W. Feng, P. A. Watson, J. C. Zinder, W. Karthaus, M. J. de la Cruz, R. K. Hite, , C. Sawyers

This study identifies allosteric interactions that prime androgen receptor dimerization and activation, revealing structural and functional mechanisms relevant to development and disease.

bioRxiv · Feb 20, 2022Biochemistry

Numerical simulation of the viral entry into a cell driven by the receptor diffusion

T. Wiegold, S. Klinge, R. P. Gilbert, G. A. Holzapfel

This paper simulates receptor-driven viral entry into a cell using a diffusion equation with boundary conditions to study how receptor mobility and initial density affect the process velocity.

bioRxiv · Oct 29, 2019Cell Biology

Assembly and early maturation of large subunit precursors

M. Chaker-Margot, S. Klinge

This study investigates the early assembly of pre-60S ribosomal subunits by examining the recruitment of assembly factors to specific domains of 25S rRNA.

bioRxiv · Dec 4, 2018Biochemistry

Modular assembly of the nucleolar large subunit processome

Z. Assur Sanghai, L. Miller, K. R. Molloy, J. Barandun, M. Hunziker, M. Chaker-Margot, J. Wang, B. T. Chait, S. Klinge

The paper determines cryo-EM structures of the nucleolar large subunit processome in different states, revealing how assembly factors prevent premature folding and enable distinct folding pathways.

bioRxiv · Nov 21, 2017Biochemistry

The complete structure of the small subunit processome

J. Barandun, M. Chaker-Margot, M. Hunziker, K. R. Molloy, B. T. Chait, S. Klinge

The paper presents the cryo-EM structure of the yeast small subunit processome, revealing its atomic model and mechanisms preventing premature pseudoknot formation.

bioRxiv · Aug 13, 2017Biochemistry