3'UTR-dependent dynamic changes in TP53 mRNA localization regulate p53 tumor suppressor activity
L. Hu, S. Misra, B. Karim, S. Kuhn, J. Salotti, S. Basu, N. Martin, K. Saylor, P. F. Johnson
This study shows that 3'UTR sequences of TP53 mRNA regulate its localization and activity by modulating CK2 phosphorylation and AMPK2/HuR dynamics.
bioRxiv · Apr 4, 2022 · PreprintCancer Biology