BiochemistrybioRxiv
Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly.
C. Stanton, J. Sun, K. Nutsch…·M. J. Bollong
This study identifies covalent compounds that inhibit NLRP3 inflammasome assembly by targeting reactive cysteines, suggesting NLRP3 as an electrophile sensor for inflammatory signaling.
DOI 10.1021/acschembio.3c00330