Author

K. Nutsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. J. Bollong· 4 shared L. Wiseman· 3 shared C. Li-Ma· 2 shared C. Stanton· 2 shared J. D. Rosarda· 2 shared T. Nguyen· 2 shared Y. Ko· 2 shared A. Stolz· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiochemistry

M. J. Bollong

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Author profile →

4 papers

Recent·Most cited

Covalent targeting as a common mechanism for inhibiting NLRP3 inflammasome assembly.

C. Stanton, J. Sun, K. Nutsch, J. D. Rosarda, T. Nguyen, C. Li-Ma, S. Kutseikin, E. Saez, J. R. Teijaro, L. Wiseman, M. J. Bollong

This study identifies covalent compounds that inhibit NLRP3 inflammasome assembly by targeting reactive cysteines, suggesting NLRP3 as an electrophile sensor for inflammatory signaling.

bioRxiv · Jun 1, 2023Biochemistry

Succinylation of a KEAP1 sensor lysine promotes NRF2 activation

L. Ibrahim, C. Stanton, K. Nutsch, T. Nguyen, C. Li-Ma, Y. Ko, G. C. Lander, L. Wiseman, M. J. Bollong

The paper identifies succinylation of KEAP1 lysine 131 as a mechanism to activate NRF2 transcriptional signaling through metabolic regulation.

bioRxiv · May 8, 2023Cell Biology

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

L. Yoon, R. C. Botham, A. Verhelle, Y. Wu, C. Cole, E. P. Tan, L. A. Massey, P. Sanz-Martinez, C. C. Chou, J. Xu, L. P. Elia, K. Lee, S. R. Labra, G. M. Kline, Q. Xiao, , S. Encalada

The paper identifies CCT020312, an mTOR-independent autophagy activator, which reduces tauopathy and prionopathy neurodegeneration phenotypes by enhancing autophagy flux and clearing protein aggregates.

bioRxiv · Sep 29, 2022 · PreprintCell Biology

Metabolically Activated Proteostasis Regulators Protect Against Glutamate Toxicity by Activating NRF2

J. D. Rosarda, K. R. Baron, K. Nutsch, M. J. Bollong, L. Wiseman

The paper shows AA147 protects neurons from glutamate toxicity by activating NRF2, highlighting its potential as a therapeutic for neurodegenerative diseases.

bioRxiv · Jun 29, 2021Biochemistry