Cell BiologybioRxiv
ATR promotes mTORC1 activity via de novo cholesterol synthesis
N. K. Tangudu, A. N. Grumet, R. Fang…·K. M. Aird
This study shows ATR enhances mTORC1 activity through cholesterol synthesis via LSS, independent of CHK1 and TSC, and this effect is amplified in p16-deficient cells.
DOI 10.1038/s44319-025-00451-3