Author

Z. Javed

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

N. Hempel· 4 shared A. T. Elhaw· 3 shared C. St. Croix· 2 shared K. M. Aird· 2 shared K. Mythreye· 2 shared L. Coffman· 2 shared P. W. Tang· 2 shared R. Phaeton· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCancer Biology

N. Hempel

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Author profile →

5 papers

Recent·Most cited

GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15

C. Chang, Y.-Y. Cheng, S. Kamlapurkar, S. R. White, P. W. Tang, A. T. Elhaw, Z. Javed, K. M. Aird, K. Mythreye, R. Phaeton, N. Hempel

This study shows GPX3 is necessary for ovarian cancer growth in vivo and promotes GDF15 expression, linking it to immune checkpoint inhibitor response.

bioRxiv · Jan 24, 2024Cancer Biology

Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer.

Z. Javed, D. H. Shin, W. Pan, S. R. White, Y. S. Kim, A. T. Elhaw, S. Kamlapurkar, Y.-Y. Cheng, J. C. Benson, A. E. Abdelnaby, R. Phaeton, H.-G. Wang, S. Yang, M. L. G. Sullivan, C. St. Croix, , N. Hempel

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.

bioRxiv · Sep 20, 2023Cancer Biology

Identification of a Novel PARP14 Site Motif and Glycohydrolase Specificity Using TLC-MALDI-TOF

Z. Javed, H. H. Nguyen, K. Harker, C. M. Mohr, P. Vano, S. R. Wallace, C. Silvers, C. Sim, S. Turumella, A. Flinn, I. Carter-O'Connell

The paper identifies a PARP14 site motif and glycohydrolase specificity using TLC-MALDI-TOF, showing sequence-dependent ADPr transfer and removal.

bioRxiv · Mar 22, 2023Biochemistry

Carcinoma associated mesenchymal stem cells promote ovarian cancer metastasis by increasing tumor heterogeneity through direct mitochondrial transfer

C. Pressimone, L. G. Frisbie, E. Dyer, R. Baruwal, G. Gorecki, Z. Javed, C. St. Croix, S. C. Watkins, M. Calderon, H. I. Atiua, N. Hempel, A. T. Pearson, L. Coffman

This study shows carcinoma-associated mesenchymal stem cells promote ovarian cancer metastasis by transferring mitochondria to cancer cells, increasing tumor heterogeneity and enhancing survival.

bioRxiv · Sep 21, 2022 · PreprintCancer Biology

HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage independence

Y. S. Kim, J. E. Welles, P. W. Tang, Z. Javed, A. T. Elhaw, K. Mythreye, S. R. Kimball, N. Hempel

This study shows that HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage independence in ovarian cancer cells.

bioRxiv · Feb 19, 2021Cancer Biology