Cancer BiologybioRxiv
KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development
S. L. Tinsley, R. A. Shelley, G. K. Mall…·B. Allen-Petersen
This study shows that KRASG12D upregulates CIP2A, which inhibits PP2A-B56α, leading to c-MYC stabilization and promoting pancreatic cancer initiation.
DOI 10.1038/s41388-024-03196-w