KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development
S. L. Tinsley, R. A. Shelley, G. K. Mall, E. R. D. Chianis, A. Dhiman, G. Baral, H. Kothandaraman, M. C. Thoma, C. Daniel, N. A. Lanman, M. Pasca di Magliano, G. Narla, L. Solorio, E. Dykhuizen, R. C. Sears, B. Allen-Petersen
This study shows that KRASG12D upregulates CIP2A, which inhibits PP2A-B56α, leading to c-MYC stabilization and promoting pancreatic cancer initiation.
bioRxiv · Jul 1, 2023Cancer Biology