SARS-CoV-2 Exploits Sexually Dimorphic and Adaptive IFN and TNFa Signaling to Gain Entry into Alveolar Epithelium
F. Giancotti, Y. Wang, S. Gurrapu, H. Chen, S. Laudato, E. Caggiano, Y. Jiang, H.-H. Ling
This study shows SARS-CoV-2 exploits sex-specific IFN and TNFα signaling to enhance ACE2 and TMPRSS2 expression in male alveolar cells, promoting viral entry and suggesting potential therapeutic targets.
bioRxiv · Jul 23, 2021 · PreprintImmunology