Author

S. M. Jay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

D. Levy· 5 shared A. Aranda· 3 shared J. W. Harmon· 3 shared L. J. Born· 3 shared N. H. Pirolli· 3 shared S. M. Kronstadt· 3 shared A. Jeyaram· 2 shared B. Mahadik· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersBioengineering

D. Levy

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

High performance anion exchange chromatography purification of probiotic bacterial extracellular vesicles enhances purity and anti-inflammatory efficacy

N. H. Pirolli, L. S. C. Reus, Z. Mamczarz, S. Khan, W. E. Bentley, S. M. Jay

This study develops a method combining tangential flow filtration and high performance anion exchange chromatography to purify bacterial extracellular vesicles, improving their purity and anti-inflammatory efficacy.

bioRxiv · May 1, 2023Bioengineering

Mesenchymal stem cell culture within perfusion bioreactors incorporating 3D-printed scaffolds enables improved extracellular vesicle yield with preserved bioactivity

S. M. Kronstadt, D. B. Patel, L. J. Born, D. Levy, M. J. Lerman, B. Mahadik, S. T. McLoughlin, A. Fasuyi, L. Fowlkes, L. Hoorens van Heyningen, A. Aranda, S. N. Abadchi, K.-H. Chang, A. T. W. Hsu, S. Bengali, , S. M. Jay

This study shows that culturing mesenchymal stem cells in 3D-printed scaffold perfusion bioreactors increases extracellular vesicle production and improves wound healing in diabetic mice.

Advanced Healthcare Materials · Apr 2, 2023Peer-reviewedBioengineering

Induced pluripotent stem cell-derived extracellular vesicles promote wound repair in a diabetic mouse model via an anti-inflammatory immunomodulatory mechanism

D. Levy, S. N. Abadchi, N. Shababi, M. R. Ravari, N. H. Pirolli, C. Bergeron, A. Obiorah, F. Mokhtari-Esbuie, S. Gheshlaghi, J. M. Abraham, I. M. Smith, E. Powsner, T. Solomon, J. W. Harmon, S. M. Jay

This study shows that extracellular vesicles from undifferentiated iPSCs outperform those from iMSCs in promoting wound healing in diabetic mice through anti-inflammatory effects.

bioRxiv · Mar 19, 2023Bioengineering

Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity

D. Dutta, N. H. Pirolli, D. Levy, J. Tsao, N. Seecharan, X. Xu, Z. Wang, X. Jia, S. M. Jay

This study evaluates how differentiation state and culture conditions affect the neuroregenerative bioactivity of extracellular vesicles (EVs) from neural stem/progenitor cells (NPSCs).

bioRxiv · Feb 15, 2023Bioengineering

Assessment of anti-inflammatory bioactivity of extracellular vesicles is susceptible to error via media component contamination

S. M. Kronstadt, L. Hoorens van Heyningen, A. Aranda, S. M. Jay

This study shows that anti-inflammatory activity of HEK293T extracellular vesicles can be falsely attributed to contamination from fetal bovine serum EVs, not the vesicles themselves.

bioRxiv · Aug 25, 2022Bioengineering

Combinatorial microRNA loading into extracellular vesicles for anti-inflammatory therapy

A. E. Pottash, D. Levy, A. Jeyaram, L. Kuo, S. M. Kronstadt, W. Chao, S. M. Jay

The paper investigates the anti-inflammatory effects of loading multiple miRNAs into extracellular vesicles and identifies a combination of miR-146a, miR-155, and miR-223 as the most effective.

bioRxiv · Jul 13, 2022 · PreprintBioengineering

The Impact of Storage Condition and Duration on Function of Native and Cargo-Loaded Mesenchymal Stromal Cell Extracellular Vesicles

D. Levy, A. Jeyaram, L. J. Born, K.-H. Chang, S. Nourmohammadi Abadchi, A. Ting Wei Hsu, T. Solomon, A. Aranda, S. Stewart, X. He, J. W. Harmon, S. M. Jay

This study evaluates how storage temperature, duration, and lyophilization affect the bioactivity and cargo retention of mesenchymal stromal cell extracellular vesicles.

bioRxiv · Jun 14, 2022Bioengineering

Sustained Released of Bioactive Mesenchymal Stromal Cell-Derived Extracellular Vesicles from 3D-Printed Gelatin Methacrylate Hydrogels

L. J. Born, S. T. McLoughlin, D. Dutta, B. Mahadik, X. Jia, J. P. Fisher, S. M. Jay

This study shows that mesenchymal stromal cell-derived extracellular vesicles can be incorporated into 3D-printed hydrogels to enable sustained release and retain bioactivity.

bioRxiv · Sep 28, 2021Bioengineering