Cancer BiologybioRxiv
WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers
E. Chan, T. Shibue, J. McFarland…·A. J. Bass
The paper identifies WRN helicase as a synthetic lethal target in microsatellite unstable cancers through CRISPR/Cas9 and RNAi screens, showing its essentiality in MSI cell lines.
DOI 10.1038/s41586-019-1102-x