S. Patankar

Toxoplasma gondii importin α shows weak auto-inhibition

This paper shows that Toxoplasma gondii importin α exhibits weak auto-inhibition due to a KKR motif in the IBB domain, differing from Plasmodium falciparum importin.

Molecular insights into the inhibition of plasmepsins by HIV-1 protease inhibitors: Implications for antimalarial drug discovery

This study investigates how HIV-1 protease inhibitors inhibit plasmepsins in Plasmodium falciparum, revealing structural insights that could guide the development of new antimalarial drugs.

ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells

This study identifies ALC1 as a key determinant of PARPi toxicity in HR-deficient cells by linking PARP-dependent chromatin remodeling to PARPi response.

Dually localized proteins found in both the apicoplast and mitochondrion utilize the Golgi-dependent pathway for apicoplast targeting in Toxoplasma gondii

The paper shows that dually localized proteins in Toxoplasma gondii apicoplast and mitochondrion use the Golgi-dependent pathway, while exclusively apicoplast proteins use a Golgi-independent pathway.

An ambiguous N-terminus drives the dual targeting of an antioxidant protein Thioredoxin peroxidase (TgTPx1/2) to endosymbiotic organelles in Toxoplasma gondii

This study identifies the N-terminal region of TgTPx1/2 as containing overlapping signals for dual targeting to apicoplast and mitochondrion in Toxoplasma gondii.

Glutathione And Thioredoxin Systems Of The Malaria Parasite Plasmodium falciparum: Partners In Crime?

The paper shows that the glutathione and thioredoxin systems in P. falciparum can functionally complement each other, compensating for the absence of key antioxidant proteins in certain compartments.