A. Deshmukh

Pyruvate Kinase M2 regulates Japanese encephalitis virus replication by interacting with NS1 protein

This study shows PKM2 reduces JEV replication by interacting with NS1, highlighting a new role for PKM2 in viral neuropathogenesis.

Characterization of Plasmodium falciparum RAP domain proteins-RAP291 and RAP070, and their association with ribosomal RNAs

This study characterizes two Plasmodium falciparum RAP domain proteins, showing they bind ribosomal RNAs and associate with the MSP-1 complex, and inhibit merozoite invasion.

Molecular insights into the inhibition of plasmepsins by HIV-1 protease inhibitors: Implications for antimalarial drug discovery

This study investigates how HIV-1 protease inhibitors inhibit plasmepsins in Plasmodium falciparum, revealing structural insights that could guide the development of new antimalarial drugs.

Structures of plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme

The paper reports the crystal structure of PfPMX zymogen, revealing a novel inactivation mechanism and molecular basis for inhibitor binding in the mature enzyme.

Artemisinin acts by inhibiting Plasmodium falciparum Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins

This study shows that Artemisinin inhibits Plasmodium falciparum Ddi1, leading to ubiquitinated protein accumulation and impaired damage recovery.

A possible role for epigenetic feedback regulation in the dynamics of the Epithelial-Mesenchymal Transition (EMT)

This paper investigates how epigenetic feedback affects EMT dynamics by integrating a feedback term into a computational model and supporting it with experimental data showing prolonged TGFβ exposure impairs reversion to the epithelial state.