A. Prasad

IgG-inspired, multivalent protein-DNA nanostructures for high-affinity, tunable, and reversible binding to biomolecular targets

This paper designs and tests a DNA-based synthetic antibody (nano-synbody) that binds SARS-CoV-2 spike proteins with high affinity and reversibility through multivalency.

Combined, yet Separate: cocktails of carriers (not drugs) for α-particle therapy of solid tumors expressing moderate-to-low levels of targetable markers

This study demonstrates that using two separate carriers for alpha-particle therapy improves tumor growth inhibition and survival in cancers with low target marker expression, without increasing radioactivity.

Using a Riemannian elastic metric for statistical analysis of tumor cell shape heterogeneity

This study compares linear and SRV metrics for analyzing tumor cell shape heterogeneity, finding SRV provides better separation and low-dimensional representation of cell morphology.

Feeder-Free Generation of Endocardial and Cardiac Valve Cells from Human Pluripotent Stem Cells

This study develops a feeder-free method to generate endocardial and cardiac valve cells from human iPSCs, showing distinct transcriptional and phenotypic features compared to vascular endothelial cells.

Aedes aegypti eggs use rewired polyamine and lipid metabolism to survive extreme desiccation

This study identifies polyamine and lipid metabolism rewiring in Aedes aegypti eggs that enable survival of extreme desiccation and subsequent hatching.

Turnover of strain-level diversity modulates functional traits in the honeybee gut microbiome between nurses and foragers

The paper examines strain-level diversity in the honeybee gut microbiome, showing it changes between nurse and forager bees, affecting functional traits.

Exact distribution of the quantal content in synaptic transmission

The paper derives the exact distribution of quantal content in synaptic transmission for different AP input patterns and validates it with electrophysiological data from mice.

Deep divergence and genomic diversification of gut symbionts of neotropical stingless bees

The paper analyzes the gut microbiota of neotropical stingless bees, finding genomic divergence and evidence of host switches in their microbial evolution.

Exact distribution of threshold-crossing times for protein concentrations: Implication for biological timekeeping

The paper derives the exact distribution of protein concentration threshold-crossing times and applies it to predict lysis times in E. coli holin gene mutants.

Evaluating the role of reference-genome phylogenetic distance on evolutionary inference

This study evaluates how reference genome phylogenetic distance affects evolutionary inference using short-read data from beluga and rowi kiwi species.

The Protein Hourglass: Exact First Passage Time Distributions for Protein Thresholds

The paper derives an analytical expression for first passage time distributions of protein thresholds, showing agreement with experimental data and analyzing noise properties under different self-regulation conditions.

Multimodal Label-free Monitoring of Adipogenic Stem Cell Differentiation using Endogenous Optical Biomarkers

This study uses multimodal imaging techniques to label-free identify adipogenic stem cell differentiation with high resolution.

Decision Support Systems based on Scientific Evidence: Bibliometric Networks of Invasive Lantana camara.

This paper introduces a bibliometric data analysis protocol using a Decision Support System to explore research themes, demonstrated with a case study on Lantana camara.

Dually localized proteins found in both the apicoplast and mitochondrion utilize the Golgi-dependent pathway for apicoplast targeting in Toxoplasma gondii

The paper shows that dually localized proteins in Toxoplasma gondii apicoplast and mitochondrion use the Golgi-dependent pathway, while exclusively apicoplast proteins use a Golgi-independent pathway.

High Throughput Screening at the Membrane Interface Reveals New Inhibitors of Amyloid-β

This study identifies 5 small molecules that inhibit amyloid-β aggregation at the cell-membrane interface, which is relevant for Alzheimer's disease.

TISMorph: A tool to quantify texture, irregularity andspreading of single cells

TISMorph quantifies cell shape features like texture, irregularity, and spreading to classify osteosarcoma cell lines treated with cytoskeletal drugs.

Metagenomic Characteristics of Bacterial Response to Petroleum Hydrocarbon Contamination in Diverse Environments as Revealed by Functional Taxonomic Strategies

The paper analyzes 16S rRNA datasets from 12 oil-polluted habitats to identify metagenomic features and biomarkers distinguishing bacterial communities in these environments.