β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
S. S. Madhavan, S. Roa Diaz, S. Peralta, M. Nomura, C. D. King, A. Lin, D. Bhaumik, S. Shah, T. Blade, W. Gray, M. Chamoli, B. Eap, O. Panda, D. Diaz, T. Y. Garcia, , J. C. Newman
This study identifies β-hydroxybutyrate as a metabolic regulator of protein solubility in aging and Alzheimer's disease, showing it reduces insolubility of pathological proteins like amyloid-β.
bioRxiv · Jul 3, 2023Physiology